Parkinson's disease is associated with hippocampal atrophy
Identifieur interne : 000963 ( Main/Corpus ); précédent : 000962; suivant : 000964Parkinson's disease is associated with hippocampal atrophy
Auteurs : Richard Camicioli ; M. Milar Moore ; Anthony Kinney ; Elizabeth Corbridge ; Kathryn Glassberg ; Jeffrey A. KayeSource :
- Movement Disorders [ 0885-3185 ] ; 2003-07.
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Abstract
Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra‐hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto‐occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P < 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini‐Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10444
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Milar Moore</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</mods:affiliation></affiliation></author><author><name sortKey="Kinney, Anthony" sort="Kinney, Anthony" uniqKey="Kinney A" first="Anthony" last="Kinney">Anthony Kinney</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</mods:affiliation></affiliation></author><author><name sortKey="Corbridge, Elizabeth" sort="Corbridge, Elizabeth" uniqKey="Corbridge E" first="Elizabeth" last="Corbridge">Elizabeth Corbridge</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</mods:affiliation></affiliation></author><author><name sortKey="Glassberg, Kathryn" sort="Glassberg, Kathryn" uniqKey="Glassberg K" first="Kathryn" last="Glassberg">Kathryn Glassberg</name><affiliation><mods:affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</mods:affiliation></affiliation></author><author><name sortKey="Kaye, Jeffrey A" sort="Kaye, Jeffrey A" uniqKey="Kaye J" first="Jeffrey A." last="Kaye">Jeffrey A. 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We compared hippocampal, and extra‐hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto‐occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P < 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini‐Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD. © 2003 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Richard Camicioli MD</name><affiliations><json:string>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</json:string><json:string>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada</json:string></affiliations></json:item><json:item><name>M. Milar Moore BS</name><affiliations><json:string>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</json:string></affiliations></json:item><json:item><name>Anthony Kinney BS</name><affiliations><json:string>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</json:string></affiliations></json:item><json:item><name>Elizabeth Corbridge BA</name><affiliations><json:string>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</json:string></affiliations></json:item><json:item><name>Kathryn Glassberg BA</name><affiliations><json:string>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</json:string></affiliations></json:item><json:item><name>Jeffrey A. Kaye MD</name><affiliations><json:string>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</json:string><json:string>Portland Veterans Affairs Medical Center, Portland, Oregon, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>dementia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Alzheimer's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MRI</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hippocampus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>atrophy</value></json:item></subject><articleId><json:string>MDS10444</json:string></articleId><language><json:string>eng</json:string></language><abstract>Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra‐hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto‐occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P > 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini‐Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD. © 2003 Movement Disorder Society</abstract><qualityIndicators><score>7.432</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1509</abstractCharCount><pdfWordCount>4708</pdfWordCount><pdfCharCount>29318</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>227</abstractWordCount></qualityIndicators><title>Parkinson's disease is associated with hippocampal atrophy</title><genre><json:string>article</json:string></genre><host><volume>18</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>7</total><last>790</last><first>784</first></pages><issn><json:string>0885-3185</json:string></issn><issue>7</issue><subject><json:item><value>Research Article</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2003</publicationDate><copyrightDate>2003</copyrightDate><doi><json:string>10.1002/mds.10444</json:string></doi><id>E99043E0A52ADEE99B3E4253D958C1A697C06514</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/E99043E0A52ADEE99B3E4253D958C1A697C06514/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/E99043E0A52ADEE99B3E4253D958C1A697C06514/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/E99043E0A52ADEE99B3E4253D958C1A697C06514/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Parkinson's disease is associated with hippocampal atrophy</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2003</date></publicationStmt><notesStmt><note>Alzheimer Research Alliance</note><note>Medical Research Foundation of Oregon</note><note>Department of Veterans Affairs</note><note>National Institutes of Health - No. AG08017; No. 5M01RR0034;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Parkinson's disease is associated with hippocampal atrophy</title><author><persName><forename type="first">Richard</forename><surname>Camicioli</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Department of Medicine, University of Alberta, Glenrose Rehabilitation Hospital, Room E‐223, 10230‐111 Avenue, Edmonton, Alberta, Canada T5G 0B7</p></note><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation><affiliation>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada</affiliation></author><author><persName><forename type="first">M. Milar</forename><surname>Moore</surname></persName><roleName type="degree">BS</roleName><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation></author><author><persName><forename type="first">Anthony</forename><surname>Kinney</surname></persName><roleName type="degree">BS</roleName><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation></author><author><persName><forename type="first">Elizabeth</forename><surname>Corbridge</surname></persName><roleName type="degree">BA</roleName><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation></author><author><persName><forename type="first">Kathryn</forename><surname>Glassberg</surname></persName><roleName type="degree">BA</roleName><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation></author><author><persName><forename type="first">Jeffrey A.</forename><surname>Kaye</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation><affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-07"></date><biblScope unit="volume">18</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="784">784</biblScope><biblScope unit="page" to="790">790</biblScope></imprint></monogr><idno type="istex">E99043E0A52ADEE99B3E4253D958C1A697C06514</idno><idno type="DOI">10.1002/mds.10444</idno><idno type="ArticleID">MDS10444</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra‐hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto‐occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P < 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini‐Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD. © 2003 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>dementia</term></item><item><term>Alzheimer's disease</term></item><item><term>MRI</term></item><item><term>hippocampus</term></item><item><term>atrophy</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2002-03-28">Received</change><change when="2002-12-16">Registration</change><change when="2003-07">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/E99043E0A52ADEE99B3E4253D958C1A697C06514/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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We compared hippocampal, and extra‐hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto‐occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (<i>P</i> < 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (<i>r</i> = 0.54, <i>P</i> = 0.015) and Mini‐Mental State Examination scores (<i>r</i> = 0.56, <i>P</i> = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Parkinson's disease is associated with hippocampal atrophy</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>PD and Hippocampal Atrophy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Parkinson's disease is associated with hippocampal atrophy</title></titleInfo><name type="personal"><namePart type="given">Richard</namePart><namePart type="family">Camicioli</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation><affiliation>Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada</affiliation><description>Correspondence: Department of Medicine, University of Alberta, Glenrose Rehabilitation Hospital, Room E‐223, 10230‐111 Avenue, Edmonton, Alberta, Canada T5G 0B7</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. Milar</namePart><namePart type="family">Moore</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anthony</namePart><namePart type="family">Kinney</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Elizabeth</namePart><namePart type="family">Corbridge</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kathryn</namePart><namePart type="family">Glassberg</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeffrey A.</namePart><namePart type="family">Kaye</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA</affiliation><affiliation>Portland Veterans Affairs Medical Center, Portland, Oregon, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2003-07</dateIssued><dateCaptured encoding="w3cdtf">2002-03-28</dateCaptured><dateValid encoding="w3cdtf">2002-12-16</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">1</extent><extent unit="tables">3</extent><extent unit="references">45</extent><extent unit="words">5361</extent></physicalDescription><abstract lang="en">Patients with Parkinson's disease (PD) may have hippocampal atrophy compared with controls. We compared hippocampal, and extra‐hippocampal volumes between PD, PDD (patients with PD who have mild cognitive impairment or dementia), Alzheimer's disease (AD) and controls using volumetric magnetic resonance imaging (MRI). Participants (10 patients with PD, 10 with PDD, 11 with AD, and 12 control subjects) had an informant interview, neurological examination, and psychometric testing. Established, reliable methods were used to measure the hippocampus, parahippocampal gyrus, temporal, frontal, and parieto‐occipital lobes. Correction for intracranial volume was carried out before comparison. There was no age difference between groups (mean age, 74 years). On the Clinical Dementia Rating scale (CDR) cognitive impairment was mild (CDR = 0.5) in the majority of PDD and AD patients. Hippocampal (P < 0.0004) volumes were smaller in the patient groups. Effect sizes compared with the control group were: PD, 0.66; PDD, 1.22; and AD, 1.81. The other volumes did not differ significantly. Among PD and PDD patients, recognition memory (r = 0.54, P = 0.015) and Mini‐Mental State Examination scores (r = 0.56, P = 0.01) correlated with left, but not right hippocampal volume. In conclusion, hippocampal volume showed a pattern (Control > PD > PDD > AD) suggesting progressive hippocampal volume loss in PD. Volumetric MRI imaging might provide an early marker for dementia in PD. © 2003 Movement Disorder Society</abstract><note type="funding">Alzheimer Research Alliance</note><note type="funding">Medical Research Foundation of Oregon</note><note type="funding">Department of Veterans Affairs</note><note type="funding">National Institutes of Health - No. AG08017; No. 5M01RR0034; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>dementia</topic><topic>Alzheimer's disease</topic><topic>MRI</topic><topic>hippocampus</topic><topic>atrophy</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>7</number></detail><extent unit="pages"><start>784</start><end>790</end><total>7</total></extent></part></relatedItem><identifier type="istex">E99043E0A52ADEE99B3E4253D958C1A697C06514</identifier><identifier type="DOI">10.1002/mds.10444</identifier><identifier type="ArticleID">MDS10444</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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